• br Methods br Transparency document

  2023-10-08

  

  Methods Transparency document Introduction Epinephrine (EP) is a critical hormone and catecholamine neurotransmitter in nervous system of mammals.1, 2, 3 It has been known to accelerate and regulate heartbeat, blood pressure, bronchodilation, mydriasis, blood sugar and lipolysis, and can he

• ATM is generally regarded to be the principal

  2023-10-08

  

  ATM is generally regarded to be the principal mediator of the G1 cyproheptadine hcl checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and type

• br Acknowledgements We would like to thank Dr

  2023-10-08

  

  Acknowledgements We would like to thank Dr. Thomas Blanpied, Sai Sachin Divakaruni, Dr. Helmut Kessels, Feline Lindhout, Dieudonnée van de Willige, and all members of the MacGillavry lab for discussions and critical reading of the manuscript. This work was supported by NWO (ALW-VENI 863.13.020, A

• br Experimental section br Acknowledgments

  2023-10-08

  

  Experimental section Acknowledgments Introduction Adipose is a major endocrine organ which releases a range of bioactive agents [1]. Selected adipose depots have been established as sites of sex steroid metabolism [1]. Subcutaneous and visceral adipose express high levels of aromatase, cap

• br Introduction O Dowd et al identified

  2023-10-08

  

  Introduction O’Dowd et al. identified a gene very similar to angiotensin type-1 receptor in 1993 (O’Dowd et al., 1993). The specific selective ligand of this receptor called APJ receptor was determined by Tatemoto et al. in 1998 as apelin (Tatemoto et al., 1998). The high expression of apelin and

• br Conclusion br Conflicts of interest br

  2023-10-08

  

  Conclusion Conflicts of interest Acknowledgements The authors are grateful to the Ministry of Food Processing Industries, Govt of India (V45/MFPI/R&D/2000 Vol.IV) and Department of Biotechnology, New Delhi, Govt. of India (BT/475/NE/TBP/20132), American Bamboo Society and Ned Jaquith Founda

• HMGN proteins are subject to extensive post translational mo

  2023-10-08

  

  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to saha inhibitor and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in [175]). T

• Although little is known about the etiopathogenesis

  2023-10-08

  

  Although little is known about the etiopathogenesis of preeclampsia, this syndrome has a major impact on maternal and fetal health worldwide, since it is responsible for 10–15% of maternal deaths [16], [17], preterm births, intrauterine growth restriction (IUGR), and fetal deaths [2]. In developing

• The proinflammatory cytokines and chemokines including

  2023-10-08

  

  The proinflammatory cytokines and chemokines, including IL-1β, TNF-α and MCP-1, mediate acute and chronic inflammation and play a role in the development of hypertension [2, [51], [52], [53]], cardiovascular diseases [4, 54] and renal injury [55, 56] in animal models and humans. Concerning the possi

• Based on our findings in this work as well

  2023-10-08

  

  Based on our findings in this work as well as the previous published data in the experimental mice model of RSV infection, we suggest that modulation of 12/15 LOX expression and/or blocking of LOX products such as 12(S)-HETE may represent potential pharmacological approaches to prevent or treat vira

• Recently two distinct small molecule inhibitors of PHGDH wer

  2023-10-08

  

  Recently, two distinct small-molecule inhibitors of PHGDH were identified using high-throughput screens, both of which inhibit de novo serine biosynthesis and show selective toxicity to cancer PF-5274857 receptor with high SSP flux [50,51]. The inhibitor NCT-503, which has an IC50 of 2.5μM, reduces

• br Materials and methods br Results

  2023-10-07

  

  Materials and methods Results Discussion Several major signaling and developmental pathways (e.g. EGFR, ALK, KRAS, TGFβ, Notch and Wnt/β-catenin) have been shown to be involved in lung carcinogenesis and they are being exploited as targets of the non-small cell lung cancer therapy (for revi

• 5 alpha reductase Vortioxetine is a multimodal antidepressan

  2023-10-07

  

  Vortioxetine is a multimodal antidepressant that acts as an inhibitor at the serotonin (5-HT) transporter (SERT), an agonist at 5-HT1A receptors, a partial agonist at 5-HT1B receptors, and an antagonist at 5-HT1D, 5-HT3 and 5-HT7 receptors (Bang-Andersen et al., 2011, Sanchez et al., 2015). Based on

• br Conclusions br Acknowledgments This research was funded

  2023-10-07

  

  Conclusions Acknowledgments This research was funded by the National Science Foundation Committee (NSFC) of China (Nos. 81171058 and 81471146) and Capital Development Scientific Research in China (Nos. 2011-5001-04 and 2014-4-5013). We are grateful for all of the participants who donated blood

• Carbetocin br Perspectives and challenges Previously the mai

  2023-10-07

  

  Perspectives and challenges Previously, the main focus of development of adenosine targets for pain was on A1Rs, due to prominent antinociception in multiple preclinical models and preliminary observations in human trials. However, delivery of agonists can be limited by other (e.g. cardiovascular

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