• br Functions essentially consisting in transport of substrat

  2023-07-31

  

  Functions essentially consisting in transport of substrates across plasma membranes Direct activation of neurotransmitter transporters elicits responses in neurons As previously mentioned (Section 2.1), nerve terminals handling classical transmitters possess transporters able to (re)capture s

• In particular we focused our attention on beta

  2023-07-31

  

  In particular, we focused our attention on beta2 adrenergic receptors, since their commercial inhibitors are effective in lowering IOP, the primary indication of glaucoma. The hypotensive action of a commercial sequence of beta2 adrenergic receptor siRNA was tested in rabbits. The results confirmed

• Derivatives of M that possess either an alkyne

  2023-07-29

  

  Derivatives of (+)-M100907 that possess either an alkyne or an azide have been synthesized. The most active enantiomer was obtained by resolution of a relatively early intermediate in the synthesis. The ability of these 20187 to maintain 5-HTR antagonist properties as (+)-M100907 was demonstrated to

• Rottlerin Whereas more research is needed to identify the

  2023-07-29

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Rottlerin that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed the behav

• The role of DHT in early teleost embryogenesis

  2023-07-29

  

  The role of DHT in early teleost embryogenesis is not entirely clear or established, however additional studies that treat fish embryos to DHT or to specific srd5a inhibitors at critical stages of development (i.e. prior to sex differentiation) will shed light on the early functions of this androgen

• PGR regulation of epithelium stroma crosstalk is proven by n

  2023-07-29

  

  PGR regulation of epithelium–stroma crosstalk is proven by numerous studies that utilize genetically engineered mouse models. Before embryo implantation, epithelial PGR mediates the progesterone signal to transcriptionally increase the Ihh levels 13, 15. Epithelial IHH then activates the stromal hed

• The R pycnus arginase was

  2023-07-29

  

  The R. pycnus arginase was 65% identical to the published B. caldovelox arginase sequence (AAB06939). Furthermore, the R. pycnus arginase gene was 62%, 45%, 36% and 22% identical to the published arginase sequences from Bacillus thuringiensis (AJI37018), Thermus thermophiles (WP_038039155), Human ar

• This study evaluated the anti tumor influences

  2023-07-29

  

  This study evaluated the anti-tumor influences of LA against HepG2 AR-C155858 in vivro, and investigated the molecular mechanisms of inducing apoptosis. Overall, our studies suggested that LA is a promising anti-cancer drug and a possible novel therapeutic agent directed toward the mitochondrial-me

• br The role of apelin in

  2023-07-29

  

  The role of apelin in respiratory diseases At present, several scientific studies have suggested that the apelin/APJ system may play an important role in the development of pulmonary diseases (Table 4). For example, in an experiment on rats suffering from acute lung injury, apelin-13 decreases th

• ASP015K To further address the mechanism of Didox s

  2023-07-29

  

  To further address the mechanism of Didox’s suppressive effects on mast cell activation, FceRI receptor ASP015K and downstream transcription factor induction were assessed. We found that Didox had no effect on FceRI surface expression, and thus concluded that Didox effects must be occurring downstr

• br Materials and methods br Results and discussion br Conclu

  2023-07-29

  

  Materials and methods Results and discussion Conclusion Introduction Free radicals produced by normal oxidative metabolism in the human body can cause chain oxidation of food, accelerate food deterioration and cause serious problems of food safety (Choe & Min, 2006). Excess free radicals

• br Technical Note Fungal spoilage of dairy products

  2023-07-29

  

  Technical Note Fungal spoilage of dairy products remains a major concern for dairy manufacturers despite the use of preventive and control approaches, including the use of chemical preservatives. Among methods that are increasingly used by industries for microbial contaminant control, biopreserva

• The reasons why antibiotic treatment may be detrimental are

  2023-07-29

  

  The reasons why antibiotic treatment may be detrimental are diverse. First, it may result in disruption of multifaceted microbe–microbe, as well as microbe–host, interactions that are key for the maintenance of homeostasis within this ecosystem. This can lead to the expansion of pathogenic microorga

• It has been reported that trehalose shows

  2023-07-29

  

  It has been reported that trehalose shows beneficial effects in a mouse model of several neurodegenerative diseases [21], [22], [23]. There are also reports showing that trehalose can improve the impaired cognitive and learning ability and reduced Aβ deposit in hippocampus of APP/PS1 transgenic mice

• br Experimental Procedures br Acknowledgments br Introductio

  2023-07-29

  

  Experimental Procedures Acknowledgments Introduction Cellular and molecular mechanisms underlying synaptic plasticity in the PSB 0777 ammonium salt are thought to be involved in memory acquisition. Synaptic plasticity is categorised into two main types, long-term depression (LTD) and long-t

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