• Stimulation of GC A by CNP was further corroborated

  2021-12-14

  

  Stimulation of GC-A by CNP was further corroborated by using a cGMP enzyme immunoassay. We could show that CNP significantly stimulated cGMP synthesis in the GC-A reporter cell line. CNP stimulation resulted in similar maximal cGMP levels compared to stimulation by ANP and BNP. Therefore, by lumines

• br GSNOR regulates SA synthesis and SA signalling The phenol

  2021-12-14

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic Cerulenin (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistance

• sirtuin 1 GPR is present primarily in the pancreas

  2021-12-14

  

  GPR119 is present primarily in the pancreas and the intestine. Activation of GPR119 increases insulin, GLP-1, GIP and PYY secretion. GPR119 agonists stimulate insulin release in a glucose-dependent manner. The glucose dependent insulin secretion (GIDS) mechanism makes GPR119 an attractive target for

• br Signaling pathways activated by pulsatile GnRH In

  2021-12-14

  

  Signaling pathways activated by pulsatile GnRH In the pituitary, GnRH acts by binding to the G protein-coupled GnRHR on the cell surface of the gonadotrope, inducing interaction of the receptor with heterotrimeric G proteins and catalyzing GTP-GDP exchange on the G protein α subunit (Lambert, 200

• Recognition and Repair of DNA Damage DNA is

  2021-12-14

  

  Recognition and Repair of DNA Damage DNA is a reactive molecule that is continually challenged by both endogenous and exogenous insults 1., 2.. Cellular metabolites and their byproducts, environmental toxins, and radiation alter the chemical structure of DNA, producing a wide spectrum of DNA damage

• ICH induced striatal lesion produced a reduction

  2021-12-14

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino jnk inhibitors transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain isch

• By regulation of synaptic glutamate concentration

  2021-12-14

  

  By regulation of synaptic glutamate concentration, glutamate transporters play an important role in limiting glutamate signaling and controlling the activation of glutamate receptors (Rimmele and Rosenberg, 2016). Reduced glutamate transport is thought to underlie the pathogenesis of numerous neurol

• A number of anti diabetic drugs

  2021-12-14

  

  A number of anti-diabetic drugs are available that inhibit α-glucosidase activity, including acarbose, voglibose and miglitol [6,7]. These inhibitors, however, also exhibit undesirable side effects, such as adverse gastrointestinal symptoms and liver toxicity [8,9]. For diabetics, it would therefore

• The main aim of our study was to identify whether

  2021-12-14

  

  The main aim of our study was to identify whether glucokinase and Irs2 were required for beta cell replication induced by short-term HF diet feeding. Glucokinase plays a critical role in regulating blood glucose levels by catalysing the rate-limiting biochemical reaction of glycolysis [26,27]. In pa

• The patterns of Fig Fig

  2021-12-14

  

  The patterns of Fig. 1, Fig. 2 emerge at the multicellular level; their dynamics can only be understood by integrating different magnitudes and feedback loops in networks incorporating the coupling between biochemical and bioelectrical signals (see Fig. 6, Fig. 8). Interestingly, this might also be

• In a mouse model of hyperhomocysteinemia a risk factor

  2021-12-14

  

  In a mouse model of hyperhomocysteinemia (a risk factor for the development of vascular dysfunction) it has been shown that myoendothelial communication is enhanced due to increased expression of Cx37 and IK1 (±)-Bay K 8644 [], allowing the propagation of endothelial signals to VSMC and thereby dec

• Gefitinib The importance of T currents in the control of

  2021-12-14

  

  The importance of T-currents in the control of thalamic GABA synaptic function is also demonstrated by the presence of T-channel-dependent long-term synaptic plasticity, either potentiation (LTP) or depression (LTD). Indeed, in the associative posterior thalamic medial nucleus, an LTP of the GABAerg

• In stark contrast to this study Zhang and

  2021-12-14

  

  In stark contrast to this study, Zhang and colleagues demonstrated that FFA4, along with FFA1, play roles in suppressing cell proliferation and promoting apoptosis in CRC sennoside treated with omega-3 PUFA [53]. In this study design, in vivo CRC was induced in mice upon treatment with the genotoxi

• As demonstrated by Bayliss Bayliss myogenic response is the

  2021-12-14

  

  As demonstrated by Bayliss Bayliss, [22] myogenic response is the ability of the blood vessels to contract in response to intraluminal pressure elevation. This is intrinsic to VSMCs, particularly in small arteries (dimeter (+)-MK 801 Maleate mg polymerization within VSMCs in response to increased i

• Here we report a new human genetic disorder

  2021-12-13

  

  Here, we report a new human genetic disorder in a patient with hypoalgesia, altered fear and memory symptoms, and a non-anxious disposition. This disorder is attributable to co-inheritance of a microdeletion in a novel pseudogene and a known FAAH hypomorphic SNP. The microdeletion is flanked by repe

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