• Fig illustrates the different signaling pathways

  2021-11-18

  

  Fig. 1 illustrates the different signaling pathways elicited or modulated by H3R activation. Collectively, the modulation of the release of histamine and other neurotransmitters through H3R activation could be linked to several neurological disorders such as sleep disorders like narcolepsy, Alzheime

• br Discussion In this study we show that

  2021-11-18

  

  Discussion In this study, we show that conditional loss of Yap/Taz in the endocardium results in a thin compact myocardium and early postnatal lethality. We also report that loss of Yap/Taz in the endocardium leads to diminished expression of Nrg1, which is a crucial endocardial-derived factor th

• br Introduction Adenosine triphosphate ATP

  2021-11-18

  

  Introduction Adenosine-5′-triphosphate (ATP) is an organic molecule (nucleoside triphosphate) which consists of adenine, ribose, and three phosphoric ion channels residues. ATP serves as a temporary carrier of energy in all living cells, so it is a common substance in any organism. In the cells,

• Our previous study provided some evidence

  2021-11-18

  

  Our previous study provided some evidence that the pre-treatment of livers with rapamycin induces the expression of HO-1 and Prx-1 (Kist et al., 2012). The present results define the dose-response curve for the induction of HO-1 and Prx-1 expression by rapamycin in normal hepatocytes. While, in the

• GPR shares a amino acid sequence identity

  2021-11-18

  

  GPR81 shares a 52% amino Cobicistat sequence identity in humans to GPR109A [1], [2], [3]. In addition, GPR81 is localized more specifically to the adipose tissue [3]. In 2008, lactate was discovered to be the endogenous ligand for GPR81 [9], [10]. Plasma lactate levels reach concentrations capable

• Because AM had limited efficacy on rodent GPR we

  2021-11-17

  

  Because (AM-3189) had limited efficacy on rodent GPR40, we used two rodent models expressing human GPR40 to demonstrate efficacy of (AM-3189). First, we used human islet transplanted nude mice. In this model, endogenous pancreatic β-cells were ablated using streptozotocin, and mice were rescued to

• Solid tumors usually present insufficient supply of oxygen

  2021-11-17

  

  Solid tumors usually present insufficient supply of oxygen, activating the hypoxia inducible factor-1 (HIF-1) pathway, which prompts an adaptive response on genes that regulate glycolytic metabolism, promoting glucose uptake through the transcription of GLUTs [54]. Increasing evidence indicates that

• Moreover we examined inhibition of GLI mediated

  2021-11-17

  

  Moreover, we examined inhibition of GLI-mediated mRNA expression by 1. Colubrinic K02288 (1) inhibited the mRNA production of PTCH in PANC1 cells in the dose-dependent manner. This result clearly shows 1 inhibits GLI-mediated transcription (Fig. 6). Discussion In this study, we identified three

• The effect of exercise on plasma ghrelin has previously been

  2021-11-17

  

  The effect of exercise on plasma ghrelin has previously been investigated mostly in humans using exercise regimens such as treadmill running, cycling, and rowing, and also in a few rodent studies and in some other animal models. While many of these clinical studies and some preclinical studies demon

• br Discussion The model of a NVU

  2021-11-17

  

  Discussion The model of a NVU described by Mathias et al. (2018) has been implemented on the macro scale (see Kenny et al. (2018b)) via a 2D cerebral tissue slice coupled to a vascular tree. In particular, further communication within the tissue slice has been implemented via extracellular ion el

• Sumoylation of transcription factors has been generally link

  2021-11-17

  

  Sumoylation of transcription factors has been generally linked to transcriptional repression and, in a few cases, to transcriptional activation [60] Accumulating evidence implies that corepressor complex subunits, including CoREST, CtBP, Daxx, NCoR1, SMRT and histone deacetylase complexes (HDACs), p

• Aberrant activity of PRC as a result

  2021-11-17

  

  Aberrant activity of PRC2 as a result of over expressed EZH2, has been frequently seen in a wide range of human cancers including breast and prostate tumors [10]. However, leukemia-associated epigenetic aberrations are not fully understood [7]. Herein, we will overview the current knowledge of epige

• Kinases belonging to the Thousand and one

  2021-11-17

  

  Kinases belonging to the Thousand and one (Tao) family are conserved throughout evolution. Three Tao proteins are encoded in the human genome (TAO1, TAO2, and TAO3), while D. melanogaster possesses a single ancestral Tao kinase (Tao-1). Like Hpo and GckIII, Tao kinases belong to the Sterile 20-like

• br HO regulation and physiology The

  2021-11-17

  

  HO-1: regulation and physiology The catabolism of cellular heme in humans and other species is mediated by the heme oxygenase (HO) family of enzymes (E.C. 1:14:99:3; heme-hydrogen donor:oxygen oxidoreductase). The HOs localize primarily to the endoplasmic reticulum (ER) where they serve, in conce

• br Ethical approve and consent to participate

  2021-11-17

  

  Ethical approve and consent to participate Consent for publication Availability of supporting data Competing interests Funding This work was supported by a grant from Key Program of National Natural Science Foundation of China (No. 81330089) and the Shanghai Science and Technology Fun

15440 records 567/1030 page Previous Next First page 上5页 566567568569570 下5页 Last page