• In modern science and technology many optimization

  2020-06-09

  

  In modern science and technology, many optimization problems need to be solved in real time, while these classical methods cannot render real-time solutions to these optimization problems, especially large-scale problems. As a new metaheuristic, particle swarm optimization (PSO) [18], [19] has prove

• While we previously demonstrated that

  2020-06-09

  

  While we previously demonstrated that TraG is inhibited by specific transglycosylase inhibitors and that enzymatic activity is strongly reduced upon mutation of the potential catalytic core (Arends et al., 2013), the enzymatic mechanism of both domains was not assigned. Here, by mass spectrometry an

• Given its high frequency it

  2020-06-09

  

  Given its high frequency, it is not surprising that different strategies have been developed to restore the sensitivity of EGFR T790M-mutant c75 to EGFR inhibition. To date, several different strategies have been evaluated in both preclinical and clinical models, but only few have been proved effect

• Although PKC in cancer cells is known to promote antiapoptot

  2020-06-09

  

  Although PKCδ in cancer Caspase-9 Colorimetric Assay Kit is known to promote antiapoptotic signaling, a cleaved form of PKCδ, δCF, has been reported to play a contrasting role in enhancing apoptosis (Reyland, 2007), and these complex functions appear to be cell-type dependent (Basu and Pal, 2010).

• br Conclusions br Acknowledgements This

  2020-06-09

  

  Conclusions Acknowledgements This work was supported by the Science and Technology Planning Projects of Guangdong Province (2014A020210027); the Major Scientific Research Projects of Universities in Guangdong Province (2016KZDXM042); the Natural Science Foundation of Guangdong Province (2015A0

• br Funding This work was supported by the National Natural

  2020-06-09

  

  Funding This work was supported by the National Natural Science Foundation of China (grant number 81671411); Beijing Natural Science Foundation (grant number 7162062); Beijing Nova Program Interdisciplinary Cooperation Projects (grant number Z161100004916045); Beijing Municipality Health Technolo

• Imeglimin hydrochloride receptor Our results on the acute ef

  2020-06-08

  

  Our results on the acute effects of THC on resting state Imeglimin hydrochloride receptor function are in line with previous neuroimaging findings. Increased perfusion after THC administration in insular and prefrontal regions has previously been reported in smaller samples (Mathew et al., 1997, Ma

• br Introduction Breast cancer is the most common malignant t

  2020-06-08

  

  Introduction Breast cancer is the most common malignant tumor in women and the second leading cause of female death [1]. In recent years, with the improvement of early detection and the emergence of new treatment methods, the mortality rate of breast cancer has been greatly reduced. However, the

• Ageing is associated with increased reactive oxygen species

  2020-06-08

  

  Ageing is associated with increased reactive oxygen species (ROS) production, oxidative stress and oxidative damage [43,44]. Overproduction of ROS can impair endothelial function by suppressing NO synthesis and scavenging NO thereby decreasing its overall bioavailability. Moreover, sustained oxidati

• CYP contributes to the metabolism of more than of

  2020-06-08

  

  CYP450 contributes to the metabolism of more than 90% of currently available drugs (Shapiro and Shear, 2002). Currently, CYP1A is the most studied xenobiotic-metabolizing isoform in fish and is often used as a biomarker for early effects of pollutants in aquatic organisms (Havelkova et al., 2007). T

• The idea that ASB can drive compartment expansion in the

  2020-06-08

  

  The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma Sitagliptin phosphate mg [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2)

• br Conclusion br Acknowledgments br Introduction Arsenic As

  2020-06-08

  

  Conclusion Acknowledgments Introduction Arsenic (As) is one of the most toxic metals derived from the natural environment in soil, air and well water. It has two oxidative states: a trivalent form, arsenite, and a pentavalent form, arsenate. The inorganic As is more toxic than organic As. A

• br Materials and methods br Results br

  2020-06-08

  

  Materials and methods Results Discussion CHIKV is an important arthropod borne virus with substantial impact on global health and cause a major viral disease that requires the development of antiviral drug to combat chikungunya disease. Virus specific proteases have particularly become an a

• We next considered the mechanism of the

  2020-06-08

  

  We next considered the mechanism of the hepatospecific decrease in CYP3A exerted by EGCG. We examined the possibility that orally administered EGCG was absorbed from the intestine and directly decreased the CYP3A expression level in the liver. Although the Illumina 384 rate of orally administered E

• Investigations of mice lacking up to three CDKs

  2020-06-08

  

  Investigations of mice lacking up to three CDKs identified the mitosis-regulating kinase CDK1 as the main essential component for the cell cycle, whereas ablation of other Microcystin-LR regulators such as CDK2, CDK4, or CDK6 did not result in defective proliferation 12, 13. Mouse models and specifi

15052 records 829/1004 page Previous Next First page 上5页 826827828829830 下5页 Last page