• br Cysteine proteases as molecular

  2020-05-26

  

  Cysteine proteases as molecular targets for trypanosomatid diseases Approaches relying on a molecular target, such as SBDD and target-based screening, have supported outstanding scientific developments in current pharmaceutical R&D. By integrating experimental and computational methods, these str

• It is worth mentioning that in

  2020-05-26

  

  It is worth mentioning that, in this study we only observed the responses of CYP450 to the short-term exposure of DSP toxins (12 h). However, the toxic effects of DSP toxins to bivalves appeared to abate with longer exposure (Pinto-Silva et al., 2005; Flórez-Barrós et al., 2011; Prego-Faraldo et al.

• Introduction Cyclin dependent kinases CDKs

  2020-05-26

  

  Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as Zalcitabine and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins/cyclin-

• br Material and methods br Results and discussion br Conclus

  2020-05-26

  

  Material and methods Results and discussion Conclusion The gene encoding the Bos taurus muscle enolase enzyme was successfully isolated and cloned in this study. Optimization of the cloning, gene VKGILS-NH2 and purification was performed and protein elution at 95% purity was achieved. An a

• br Introduction Cancer related inflammation is associated

  2020-05-25

  

  Introduction Cancer related inflammation is associated with poor prognosis and reduced survival in numerous human malignancies. Expansion of myeloid derived immune receptor tyrosine kinase in response to tumor-secreted factors largely contributes to the heightened systemic and intra-tumoral infl

• br Introduction Concern has been raised over free estrogens

  2020-05-25

  

  Introduction Concern has been raised over free estrogens (estrone [E1], 17ß-estradiol [E2] and 17α-ethynylestradiol [EE2] particularly) in the past decade due to their endocrine disrupting effects on environmental biota [1], [2]. Estrogens are excreted by vertebrates primarily as sulfate or glucu

• COH inhibited global SUMOylation in

  2020-05-25

  

  COH000 inhibited global SUMOylation in MMP-2 Inhibitor II and blocked the E1 catalyzed attachment of SUMO to the corresponding conjugating enzyme Ubc9, but not the attachment of ubiquitin or NEDD8 to their respective E2s, confirming inhibition and specificity in cellulo. Consistent with previous st

• br Introduction Protein modification by ubiquitin

  2020-05-25

  

  Introduction Protein modification by ubiquitin and ubiquitin-like proteins is one of the most common and important regulatory mechanisms in biology (Finley et al., 2004, Pickart, 2004). Ubiquitination is carried out by an enzymatic cascade consisting of three steps. In the first step, ubiquitin i

• In the case of high fidelity polymerases we

  2020-05-25

  

  In the case of high-fidelity polymerases, we propose that water is used to achieve negative selection against nucleotide binding. With specialized DNA polymerases, we propose that nucleobase desolvation plays a different yet important role in allowing these enzymes to replicate damaged DNA. In this

• The first purpose of the current study was to

  2020-05-25

  

  The first purpose of the current study was to characterize a standardized experimental model of postprandial hyperlipidemia in various rodent species. To our knowledge this study provides the most comprehensive and systematic evaluation of rodent models of postprandial hyperlipidemia to date. We ada

• Cultured cells or mouse lung tissues were harvested and

  2020-05-25

  

  Cultured cells or mouse lung tissues were harvested and lysed in Radio-Immunoprecipitation Assay (RIPA) buffer (0.05 mol/l Tris–HCl pH 7.4, 0.15 mol/l NaCl, 0.25% deoxycholic acid, 1% NP-40, 1 mmol/l ethylenediamine tetraacetic Hordenine (EDTA), 1 mmol/l phenylmethylsulfonyl fuoride, 1 μg/ml aprot

• Introduction The term myeloproliferative disorders was first

  2020-05-25

  

  Introduction The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myelopro

• Introduction Rotavirus RV a member of Reoviridae family is

  2020-05-22

  

  Introduction Rotavirus (RV), a member of Reoviridae family, is a non-enveloped virus which has a double-stranded RNA genome of 11 segments surrounded by three concentric protein layers. It has been reported to cause estimated 25% of moderate-to-severe illnesses (Kotloff et al., 2013) and 30% of tot

• br Acknowledgement AM and SK thank ICMR New

  2020-05-22

  

  Acknowledgement AM and SK thank ICMR, New Delhi, India for the financial assistance BIC/12(32)/2012. SK is the recipient of JRF from the project. RK and GJ thank Bristol-Myer Squibb (Grant # 34003085), USA for financial support. Introduction Proliferating Cell Nuclear Antigen (PCNA) is a high

• The mechanisms in the central nervous system

  2020-05-22

  

  The mechanisms in the central nervous system (CNS) controlling the sympathetic tone of the Idelalisib are associated to behavioral strategies, such as those involved in response to stress. In this regard, morphine withdrawal induces profound and severe stress reactions evidenced by enhancement of N

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